Effect of immunoglobulin G (IgG) interchain disulfide bond cleavage on efficacy of intravenous immunoglobulin for immune thrombocytopenic purpura (ITP)
نویسندگان
چکیده
منابع مشابه
Relative labilities of the two types of interchain disulfide bond of rabbit gamma G-immunoglobulin.
A molecule of rabbit yG-globulin’ evidently consists of four polypeptide chains held together by interchain disulfide bonds and noncovalent interactions. Each molecule comprises a pair of similar or identical “light” chains having an approximate molecular weight of 20,000, and another pair of “heavy” chains of weight 50,000 to 55,000 (2-7). Each light chain is linked to a heavy chain and the tw...
متن کاملRelative Labilities of the Two Types of Interchain Disulfide Bond of Rabbit y G-Immunoglobulin*
A molecule of rabbit yG-globulin’ evidently consists of four polypeptide chains held together by interchain disulfide bonds and noncovalent interactions. Each molecule comprises a pair of similar or identical “light” chains having an approximate molecular weight of 20,000, and another pair of “heavy” chains of weight 50,000 to 55,000 (2-7). Each light chain is linked to a heavy chain and the tw...
متن کاملUpdate on chronic immune thrombocytopenic purpura (ITP)
Platelet production and circulation Thrombopoietin (TPO), the major cytokine affecting all phases of platelet production, is produced primarily by the liver and binds to the c-Mpl receptor located on platelets, stem cells and megakaryocytes. Upon stimulation, pluripotential stem cells produce cells committed to megakaryocyte differentiation. These cells initially undergo mitosis followed eventu...
متن کاملcomparison of intravenous immunoglobulin (ivig) and intravenous anti-d for treatment of acute idiopathic thrombocytopenic purpura
introduction: acute idiopathic thrombocytopenic purpura (itp) is an autoimmune bleeding disorder of childhood caused by production of auto antibodies against platelets. the aim of the present study was to compare the efficacy of intravenous immunoglobulin (ivig) and intravenous anti-d(iv anti-d) in itp treatment. methods and materials: in a clinical trial, 43 children with acute itp referred to...
متن کاملVery low-dose intravenous immunoglobulin for treatment of immune thrombocytopenic purpura.
A nine-year-old boy presented to us with complaints of fever, cough and pin point red spots over the body for 2 days. He also had one episode of bleeding from nose. On examination he had petechial spots scattered all over the body. There was no hepato-splenomegaly. Complete blood count showed haemoglobin of 11.4 g/dL, white blood cell 8000/mm3 and platelet 8,000/mm3. Peripheral blood smear was ...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2010
ISSN: 0009-9104
DOI: 10.1111/j.1365-2249.2010.04255.x